Diabetes, the “The Peoples Worst Enemy” is drastically increasing and cause huge problems.
Diabetes disease leading to primary and secondary complication and are the major causes of disability and death:

1.  Heart diseases
2.  Stroke
3.  Arthritis
4.  High blood pressure
5.  High Cholesterol
6.  Diabetes Neuropathy
7.  Retinopathy
8.  Gastro paresis
9.  Erectile dysfunction
10.  Urinary  and yeast infection
11.  Kidney failure
12.  Gangrene
13.  Tumor diseases
14.  Blindness.

What is the reason for Diabetes?
This question is basic and most important in order to cure the disease and the answer is Homeostasis and the signaling system.

A healthy body is in total balance (Homeostasis) and cover following:
1.  Temperature regulation of the body.
2.  Mineral (Iron) uptake in the small intestine.
3.  Energy
4.  Blood composition
5.  Blood sugar regulation
6.  Blood lipids
7.  Osmoregulation
8.  Pressure
9.  Calcium
10.  Acid- Base
11.  Volume
12.  Hemostasis
13.  sleep
14.  Extra cellular fluid
15.  Innate Immune System
16.  Immune defense system
17.  Stress
18.  Peyer’s Patch cell system
19. Small Intestine

The central actor in homeostasis, the stabilization of internal milieu is Insulin for regulation and transportation of the glucose from the blood into all the cells. The cells need glucose the entirely time to balance between low level and to high level of glucose in the blood which is regulated between Insulin and Glucagon.  

Insulin action, is dependent on the Homeostasis in the Small Intestine and the lymphoid system in the small intestine named Peyer’s Patch Cell System, because Small Intestine is the key center for keeping the overall homeostasis in healthy condition as the digestion occur to > 90% in that part of the Gastrointestinal Tract and the Essential Nutrients uptake into the blood occur there as well.

Homeostatic regulation in the Small Intestine is not fully understood but the Innate Immune System plays a central role for controlling the cell signaling system.

There is no another hormone that has so many and wide range actions as Insulin is the major actor in control of carbohydrates, lipid and protein metabolism such as:

1.  Glucose uptake in muscle and  Adipose tissue           
2.  Glycolysis
3.  glycogen synthesis
4.  protein synthesis
5.  uptake of ions  (especially K+ and PO4 -3)      

At the same time Insulin restrains processes that release stored energy as:

1.  Gluconeogenesis
2.  Glucogenolysis
3.  Lipolysis
4.  Ketogenesis
5.  Proteolysis

The Homeostasis and the signaling system are the most important factors for keeping the body in complete harmony and free from diabetes and other diseases.  

Cell signaling is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity as well as normal tissue homeostasis. Errors in cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, diseases may be treated effectively without causing adverse reaction.

Cells communicate with one another through direct cell membrane contact or by releasing signal molecules into the blood stream, according to the National Cancer institute. Cell-signaling is often referred to as intracellular communication. If a cell loses the ability to communicate with neighboring cells, it may become a cancer cell.

Cell signaling system

Juxtacrine Signaling

  • When an inducing cell uses juxtacrine signaling to communicate with surrounding cells, proteins from the inducing cell interact with receptor proteins from nearby cells. Three different kinds of juxtacrine signaling exist. The first involves a protein from one cell binding to a protein on a neighboring cell. The second involves a receptor on one cell binding to its ligand on the extracellular matrix secreted by a neighboring cell; the third type of juxtacrine signaling involves one cell transmitting a signal directly through a conduit in its cytoplasm to the cytoplasm of a neighboring cell.

Paracrine Signaling

  • With paracrine signaling, the inducing cell only communicates with nearby targeted cells. An example of this, according to scientists at the University of California, Berkeley, is the conduction of an electrical signal from a nerve cell to a muscle cell. The signaling molecule in this paracrine signaling process is a neurotransmitter.

Autocrine Signaling

  • Autocrine signaling occurs when a cell responds to its own signaling molecules that were produced at an earlier point in time. Some examples of this type of signaling include lipophilic and prostaglandins binding to membrane receptors.

Endocrine Signaling

  • Endocrine signaling occurs when cells release signaling molecules into the blood stream that eventually reach the cell they're trying to communicate with. Signaling molecules are usually released by the endocrine gland and travel to cells throughout the entire body. Some examples of hormones with signaling molecules are testosterone, progesterone, and thyroid. These hormones help to regulate transcription and depend on the presence of water-soluble molecules like insulin, glucagon, histamine, and epinephrine.

Diabetes – Homeostasis imbalance leading to incorrect cell signaling systems

The balance in the blood is regulated by Insulin and Glucagon and when the Glucose level is > 5 mmol/l blood the beta-cells in the pancreas increase their output of insulin and C-peptide (Connecting peptide) and during that time the alpha-cells that produce glucagon in the pancreas remain quiet and hold their hormone.

A fall in blood glucose under 4 mmol/l blood leads to decrease in insulin secretion and the alpha-cells become active and deliver glucagon. It is the balance between insulin and glucagon, the resulting molar ratios of these two hormones that controls metabolism.

Diabetes is the results of homeostasis imbalance and dysfunction of the cell signaling system and that is the reason for Diabetes Mellitus. The cells develop so called resistant to insulin and make it impossible for insulin to activate the glucose transport into the cells and instead the glucose level in the blood reach dangerous levels.

The basic reason for development of diabetes is that the innate immune system takes care of mycotoxins from pathogenic bacteria and fungus and by that cause homeostasis imbalance and shut down the signaling system.  

How to be able to treat and cure diabetics from their severe disease and its primary and secondary complication is urgently needed in order to prevent disability and death.

That question is one of the most important medical issues we have to solve.

During long time of testing and during several years on the market it seems that our product fulfill the demand to control the glucose level in the blood by turn on the cell signal system so the insulin can act and at the same time to increase the quality of life to normal without any side effects and avoid disability and death.